Prostate cancer cells synthesize and secrete prostasomes into body fluids. Prostasomes are prothrombotic by virtue of their expression of: (1) long-chain polyP, which can promote FXII auto-activation and initiation of thrombin via the intrinsic pathway; and (2) TF, which, in complex with factor VII(a), initiates coagulation through the extrinsic pathway. Professional illustration by Erica Sparkenbaugh.