Genome-wide CN architecture of 148 DLBCL patients. (A) A genome-wide linear representation of the CN profile, summarized at the gene level, across all 148 samples, with gains in red, and deletions in blue. Selected genes with recurrent somatic genomic aberrations are annotated with arrows. Germline CN polymorphisms have been subtracted from this plot. (B) Stacked horizontal-bar plot indicating the absolute number of gains (on right) and deletions (on left) of the selected genes from panel A. Different colors represent the aberration distribution according to COO classification, with asterisks indicating whether there is an enrichment of the aberration in a particular subtype. (C-E) Two-color FISH assays, with red probe interrogating a target gene of interest (LCOR, RCOR1, and NCOR1) and green probe interrogating an established tumor suppressor on the same chromosomal arm (PTEN, SOCS4, and TP53) as a reference.