Somatic and germ-line TRAF3 mutations detected in canine lymphoma tumors. An overview of all nonsilent mutations affecting TRAF3 in the context of predicted protein domains. The height of each glyph indicates the frequency at which the mutation was observed in the cohort. Mutations were detected along the length of the protein with recurrent somatic SNVs introducing a premature stop at a single codon (423) in 3separate patients. Thirty-eight of the 48 detected mutations including indels and SNVs introduced a premature stop or frameshift. Details of all TRAF3 mutations found in our cBCL cohort are available in supplemental Table 6.