Figure 3
Figure 3. Bidirectional effects of TGF-β. Low concentrations of TGF-β stimulate proliferation of My-HSCs, whereas Ly-HSCs are growth inhibited. A higher dose of TGF-β inhibits proliferation, irrespective of HSC subtype, and induces quiescence via SMAD2/3-SMAD4-dependent expression of p57Kip2.

Bidirectional effects of TGF-β. Low concentrations of TGF-β stimulate proliferation of My-HSCs, whereas Ly-HSCs are growth inhibited. A higher dose of TGF-β inhibits proliferation, irrespective of HSC subtype, and induces quiescence via SMAD2/3-SMAD4-dependent expression of p57Kip2.

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