Downregulation of c-Jun reduces cytokine production by lymphoma cells. (A-B) Multiplexed cytokine array was used to detect cytokines released by OCI-Ly3 and OCI-Ly10 cells during 48 hours of culture in complete medium. Results are shown as the mean fluorescence intensity (MFI) determined in duplicates from 2 independent experiments. (C-D) OCI-Ly3 or OCI-Ly10 cells were cocultured with HS-5 mesenchymal cells or supernatants (sup) from HS-5 cells (30%) for 48 hours. Concentrations of VEGF and FGF2 were measured by using a cytokine multiplex. Results are presented as mean + SD of duplicates from 2 independent experiments. FGF2, basic fibroblast growth factor; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; GRO, growth-regulated oncogene; IFN, interferon; IP-10, interferon-induced protein 10; MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; MIP, macrophage inflammatory protein; TGF, transforming growth factor; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.