Kinetics of hematopoiesis in the leukemic spleen. (A-B) Absolute numbers of LKS⁺ (A) and LKS⁻ (B) cells in the leukemic spleen. (C-D) Absolute numbers of LT-HSCs, ST-HSCs, MPPs (C), GMPs, CMPs, and MEPs (D) in the leukemic spleen. (E) Ki67 staining of LKS⁺ and LKS⁻ cells in the leukemic spleen. (F) BrdU staining of LKS⁺ and LKS⁻ cells in the leukemic spleen. Data are represented as the mean ± standard error of the mean (n = 12; 3 independent experiments). Ctrl, control. *P < .05; **P < .01; ***P < .001.