Figure 6
![Figure 6. Cytokine analysis of conditioned medium generated by BMSCs with reduced TERC expression. (A) A commercial cytokine array (RayBio Human Cytokine Antibody Array 6 [60]) was used to assess the levels of cytokines secreted into the medium at 72 hours by untreated N-BMSCs, and 72 hours after transfection with negative control-siRNA, (siNC-BMSCs) and siTERC-RNA (siTERC-BMSCs) (n = 4 for each of the 3 groups). (B) A number of cytokines associated with hematopoiesis such as SCF, SDF-1, Angiogenin, and IL6 were found to be decreased between 18% and 30% in siTERC-BMSCs compared with siNC-BMSCs, although changes in SCF and SDF-1 were not significant when compared with N-BMSCs (*P ≤ .05).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/125/5/10.1182_blood-2014-06-566810/4/793f6.jpeg?Expires=1735842913&Signature=KqFYvlrgtIPIUhvCNiWztniaugV5KL8pIVJl7yQOGzCDagkJWwGKTroojiexRc65gCrIBRRw0LQ~kQu1dsfBGGq0r7JPJ4f8hav7qneaKVO~w0-~tPX92Yi~680zJZ-ElW7biJ5X0cWMZxxE9ovahnEorqz4MPlwOO-OLorUyONMMxnd8adDVxNN9~jxK0nM7VGwAEpbPUaRkGJE6dmtJgzQAUDv1-O58-6OINjmr7wBwqKH-17kZRqMSPJ98s3kKcUhCtXdXLO14495z~pB8AEoO0gHPoILAl1~T4irnCMoFcExeM2dFE5rOlqjuk5KTMR2g1dp01Grim~uxVtoAA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Cytokine analysis of conditioned medium generated by BMSCs with reduced TERC expression. (A) A commercial cytokine array (RayBio Human Cytokine Antibody Array 6 [60]) was used to assess the levels of cytokines secreted into the medium at 72 hours by untreated N-BMSCs, and 72 hours after transfection with negative control-siRNA, (siNC-BMSCs) and siTERC-RNA (siTERC-BMSCs) (n = 4 for each of the 3 groups). (B) A number of cytokines associated with hematopoiesis such as SCF, SDF-1, Angiogenin, and IL6 were found to be decreased between 18% and 30% in siTERC-BMSCs compared with siNC-BMSCs, although changes in SCF and SDF-1 were not significant when compared with N-BMSCs (*P ≤ .05).
