Figure 2
![Figure 2. Potency of 14E11 and O1A6 varies depending on [TF]wall. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with FXI antibody 14E11 or O1A6 (20 μg/mL) and was perfused over collagen/TF surfaces at 100 s−1 (constant Q). (A-C) Platelet deposition on collagen was unaffected by FXI antibodies despite the difference in [TF]wall. (D-E) O1A6 showed inhibitory effect on fibrin generation at low and medium [TF]wall. (D) 14E11 only reduced fibrin generation at low [TF]wall. (F) Neither of the antibodies caused reduction in fibrin at high [TF]wall. *P < .05; **P < .01.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/12/10.1182_blood-2015-04-641472/4/1494f2.jpeg?Expires=1735509578&Signature=12dpL16E3hjICIvJTuwzpfq021KqHWMr9nh6DZEQd5hUwAMO4zGFlsGkSU5mxbsMISRvanPAZbFEH4aoJ796LOiPJ64LCq0KyDKDZ0PurS~SHHp3TG6P1Ydjeaqw1Y03d87EP9MbpZYlvHV10Ver05~010pl6KUaz97rhwtcVGVCYH7ImorZqq7BkMubpobqTfp9QcLXTIIFWpkVGvZ2A5LQmnWp1RLfefCiahQ8DnceHbnhwZNDFVdDdB76GkD9HsPV16lf-sNkHFrLJeUVQtNozAeQ~qOT9l6lyFxG5tvl2qy6Ix5ZXG5gM0D~9qjh2SKouRyC4mHeRz0ZX5DTyA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Potency of 14E11 and O1A6 varies depending on [TF]wall. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with FXI antibody 14E11 or O1A6 (20 μg/mL) and was perfused over collagen/TF surfaces at 100 s−1 (constant Q). (A-C) Platelet deposition on collagen was unaffected by FXI antibodies despite the difference in [TF]wall. (D-E) O1A6 showed inhibitory effect on fibrin generation at low and medium [TF]wall. (D) 14E11 only reduced fibrin generation at low [TF]wall. (F) Neither of the antibodies caused reduction in fibrin at high [TF]wall. *P < .05; **P < .01.
