Figure 4
![Figure 4. PPXbd inhibits fibrin and thrombin generation on collagen/low [TF]wall at arterial shear rate. (A-B) Anticoagulated whole blood (CTI, 4 μg/mL) was treated with PPXbd (250 μg/mL) and was perfused over collagen or collagen/low [TF]wall surface at 1000 s−1 under constant pressure drop conditions (constant ΔP). Platelet deposition on collagen was unaffected by PPXbd. Fibrin generation was inhibited by PPXbd on (D) collagen/low [TF]wall surface but not on (C) the collagen-alone surface. (E-F) Consistent with the reduction in fibrin on collagen/low [TF]wall, thrombin generation at low [TF]wall was also lowered by PPXbd after 300 seconds. *P < .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/12/10.1182_blood-2015-04-641472/4/1494f4.jpeg?Expires=1735509397&Signature=ArjDSKvjXIC~IikVLUo-9CKUqd6d6wiAE9q8PjvDPdMSX1VibND-sQv1kYYpCKLv8Rq8YnpUOfSWk5HdDXb4S-aSkbzjNbm3r-ISEh75ehCP0T-4UITCcO6BimfqoTpOUrLp0SxYiQkmJWd5n~zK3ijWU0HEkHCbRgXGhM-4O4XhsaVwoHKZApGVonrXmN1pC6JFHWC7UMddzhn6FBU6u441mXDnYFiThX-OodtNQXk8We5mSSDCfsQ33OooGxbGsO75I8Gr5eleGtyejWjX5Z3P-j6RdkVQeI-bvtJB2CXsh5yZiUAU~ev3wliIe7e2EO5pGI~C-4IfSIJgH0tXuQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PPXbd inhibits fibrin and thrombin generation on collagen/low [TF]wall at arterial shear rate. (A-B) Anticoagulated whole blood (CTI, 4 μg/mL) was treated with PPXbd (250 μg/mL) and was perfused over collagen or collagen/low [TF]wall surface at 1000 s−1 under constant pressure drop conditions (constant ΔP). Platelet deposition on collagen was unaffected by PPXbd. Fibrin generation was inhibited by PPXbd on (D) collagen/low [TF]wall surface but not on (C) the collagen-alone surface. (E-F) Consistent with the reduction in fibrin on collagen/low [TF]wall, thrombin generation at low [TF]wall was also lowered by PPXbd after 300 seconds. *P < .05.
