Figure 5
![Figure 5. PPXbd inhibits pathways downstream of FXIIa. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with (A) 14E11 (20 μg/mL) to inhibit FXIIa activation of FXI or (B) O1A6 to block FIX activation by FXIa and was perfused over collagen/low to medium [TF]wall surface at 100 s−1 under constant flow rate mode (constant Q). Adding PPXbd to 14E11-treated blood caused significant reduction in fibrin signal after the first 200 seconds. PPXbd showed no effect on fibrin generation when it was added to O1A6-treated blood.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/12/10.1182_blood-2015-04-641472/4/1494f5.jpeg?Expires=1735507910&Signature=L5XD0mR5uEGyT6z2fzI5kZKSTWm8cH-kum5uHaLms3jI6BXLaF9736NpEYtgJcWzgLAqfoEBfH8UW69UYwM6X5Cvq~omhsFlistaTYBixpRYvDnUP-SZiFI6phZi8qIfvyG3E3j7bT7-nKHe-YGg3m85GMtoEK4XZ0xQ1PSEV33grhqjHvrZgMk46QU1VvTTjTAZi8BjbdwAzRPQJQpKepX1QTQU0dV8jZG5okN3EOgEu~-gpqzQe3NMnEeIimNVJVXhQMy6gIpop0e~Cet2C4~2Rd9i6GRjedvJiSQHN2iRQ1ut5M2y2BZp-Bm0If1s9eEj1aDFU5vgnZ5r2YGSYg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PPXbd inhibits pathways downstream of FXIIa. Anticoagulated whole blood (CTI, 4 μg/mL) was treated with (A) 14E11 (20 μg/mL) to inhibit FXIIa activation of FXI or (B) O1A6 to block FIX activation by FXIa and was perfused over collagen/low to medium [TF]wall surface at 100 s−1 under constant flow rate mode (constant Q). Adding PPXbd to 14E11-treated blood caused significant reduction in fibrin signal after the first 200 seconds. PPXbd showed no effect on fibrin generation when it was added to O1A6-treated blood.
