Kaplan Meier curves for TTFT. (A) Subset #2 exhibits significantly shorter TTFT compared with non–subset #2/IGHV3-21 CLL. (B) No difference regarding TTFT between non–subset #2/IGHV3-21 cases and the remaining CLL. Subset #2 exhibits TTFT similar to that of U-CLL independently of IGHV gene mutational status.