Course and outcome of immunosuppressive therapy. *All 18 patients from the 2 sites not following the IST protocol were excluded regardless of their actual therapy. **Patients not yet achieving PR but continuously improving their FVIII activity until day 21 (while on prednisolone) or day 42 (while on cyclophosphamide and prednisolone) remained on the current treatment as per protocol. CTX, cyclophosphamide; P, prednisolone.