Defects of NK cytotoxic activity are not sufficient to induce HLH-like development in mice.Stx11^−/− (open bars/open squares), T⁺NK^Stx11− (gray bars/gray circles), and control (black bars/black squares) mice were infected with 200 PFU of LCMV-WE. Clinical and biochemical parameters were determined after infection. (A) Body weight and body temperature. (B) White blood cell counts were analyzed on day 12 postinfection. (C) Red blood cell, hematocrit, and platelets counts on day 12 postinfection. (D) The time course of neutrophils counts. (E) Lymphocytes counts were analyzed on day 12 postinfection. (F) Absolute numbers of CD8 lymphocytes in blood on day 12 postinfection. (G) Serum IFN-γ on day 8 postinfection. (H) LCMV titers in liver on day 21-postinfection. Data (mean ± SEM) are representative of 2 independent experiments with at least 3 mice in each group. Dotted lines represent minimal normal values for control mice. Statistical analysis was performed using 1-way ANOVA or Student t test. *P < .05; ***P < .001.