Maximum tumor size reduction by quantitative CD30 expression in DLBCL patients. Blue-shaded area represents the 95% confidence band around the point estimates; solid line is a smooth curve based on nonparametric regression. Figure includes patients who have both postbaseline radiographic response assessments and CD30 IHC expression data. Maximum tumor size decrease by CD30 expression as assessed by (A) central visual review and (B) by computer-assisted methods.