Increased PKR expression is associated with poor survival and shortened remission for acute leukemia patients. RPPA of CD34⁺ cells collected from PB and BM of 414 newly diagnosed AML patients was used to classify patients into 2 groups based on PKR expression level (highest one-third vs lowest two-third expression). Kaplan-Meier analysis was used to measure: (A) OS probability of all patients (n = 414), (B) remission duration for those patients who achieved complete remission (n = 230), (C) survival probability for those patients with unfavorable cytogenetics (n = 195), and (D) remission duration of patients with unfavorable cytogenetics (n = 80). Median (weeks) and P value for each group were calculated by Cox proportional hazard modeling (ie, Cox-Mantel test).