P1V1 and P1V3 mice are protected from impairments in lung function in Ova-induced allergy. P1V1 and P1V3 mice are protected from methacholine-induced increase in lung resistance (A) and loss of lung compliance (B) during Ova-induced lung allergy. Lung allergy was induced with Ova or mock-induced in P1V1, P1V3, and PVWT mice as in Figure 6, and lung function was assessed by challenge with rising concentrations of methacholine, measuring lung resistance (A) and compliance (B). Bar graphs show the dose of methacholine required to increase lung resistance by 200% over basal (A) or to reduce lung compliance by 50% compared with basal (B). Data are mean ± SEM of n = 4 to 6 mice/group; statistics are 1-way ANOVA with Bonferroni multiple comparisons test between Ova-sensitized groups.