Platelet-derived VWF mediates ischemic stroke injury. This figure shows representative coronal brain sections 24 hours after induction of transient middle cerebral artery occlusion in wild-type mice (WT), mice completely lacking VWF (VWF KO), mice expressing VWF only in platelets (VWF PLT), and mice expressing VWF only in endothelial cells (VWF EC). White indicates areas of infarct; pink shows unaffected brain tissue. This figure has been modified from Figure 4A in the article by Verhenne et al that begins on page 1715. Professional illustration by Luk Cox, Somersault18:24.