BCL6 translocation fragile zone overlaps with lncRNA transcript. The tracks in this Integrative Genomics Viewer snapshot show: Line 1, the BCL6 gene (blue, transcribed from negative strand); Line 2, the lncRNA (shown in green and transcribed from positive strand; gene called lnc-RP11-211G3.3.3-1); Line 3, the density of patient BCL6 translocation breakpoints adapted from previous publication1 (tan line graph illustrating the number of BCL6 breakpoints counted in 500-bp sliding window with steps of 50 bp; the y-axis range of this graph is 0-48); Line 4, the actual location of BCL6 breakpoints described in line 3 (black vertical lines are distributed over 3 layers for clarity); Line 5, the fragile zone of 2156 bp that encompasses 90% of the breakpoints (red bar); Line 6, AID off-target mutation zone in the Ramos cell line (light purple bar)5 ; Line 7, the H3K27Ac chromatin immunoprecipitation–seq read density in human tonsil germinal center B cells (gray, GSM1519135)5 ; Line 8, the H3K4me3 chromatin immunoprecipitation–seq read density in the human lymphoma (DLBCL) cell line, OCI-Ly1 (dark purple); the y-axis range of this graph is 0 to 60.1 The lncRNA gene overlaps with >87% of the BCL6 breakpoints.
