miRNA signatures for DLBCL subgroups and comparative analysis in other subgroups, cell lines, and normal B-cell subsets. (A) ABC-DLBCL vs GCB-DLBCL. Eight miRNAs were able to distinguish ABC-DLBCL from GCB-DLBCL. GCB-DLBCL-related miRNAs are also expressed in CB and at least 1 GCB-DLBCL cell line, whereas only miRNA-155 from ABC-DLBCL shows association with activated B cells and ABC-DLBCL cell lines. Here, we chose an 80% probability threshold to distinguish the 2 DLBCL subgroups. (B) PMBL vs DLBCL. Five miRNAs were able to distinguish PMBL from DLBCL. (C) Differential miRNA expression between 3 subgroups of DLBCL.