Figure 2
Figure 2. Posttransplant Tc17 cells are highly proinflammatory and plastic in cytokine profile. (A-D) Donor CD8+ T-cell cytokine expression was examined after allogeneic (B6.IL-17CreRosa26eYFP→B6D2F1) transplant. Representative FACS analysis showing splenic IL-17A, IFNγ, IL-22, IL-13, TNF, IL-10, and GM-CSF cytokine expression by CD8+YFPneg or CD8+YFP+ populations after short-term in vitro restimulation (A) d7 or (B) d21 posttransplant. (C-D) Frequencies of cytokine-expressing CD8+ T cells isolated from (C) spleen or (D) liver and assessed 1 to 3 weeks post–allo-SCT as indicated (mean ± SEM, n = ≥5 mice/group; *P < .05, **P < .01, ***P < .001, ****P < .0001).

Posttransplant Tc17 cells are highly proinflammatory and plastic in cytokine profile. (A-D) Donor CD8+ T-cell cytokine expression was examined after allogeneic (B6.IL-17CreRosa26eYFP→B6D2F1) transplant. Representative FACS analysis showing splenic IL-17A, IFNγ, IL-22, IL-13, TNF, IL-10, and GM-CSF cytokine expression by CD8+YFPneg or CD8+YFP+ populations after short-term in vitro restimulation (A) d7 or (B) d21 posttransplant. (C-D) Frequencies of cytokine-expressing CD8+ T cells isolated from (C) spleen or (D) liver and assessed 1 to 3 weeks post–allo-SCT as indicated (mean ± SEM, n = ≥5 mice/group; *P < .05, **P < .01, ***P < .001, ****P < .0001).

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