Ezh1 loss did not cause any hematologic malignancies. (A) PB cell counts in Ezh1^−/− mice up to 16.5 months after birth. WBC, Hb, and Plt counts in the PB from WT (n = 5) and Ezh1^−/− (n = 5) mice are shown as the mean ± standard deviation (SD). (B) The proportions of myeloid (Mac-1⁺), B220⁺ B, and CD4⁺ or CD8⁺ T cells among CD45⁺ donor-derived hematopoietic cells in the PB at the time points indicated. Data are shown as the mean ± SD (n = 5). (C) Absolute numbers of total BM cells (left panel) and long-term (LT), short-term (ST), and multipotent progenitors (MPPs) in a unilateral pair of the femur and tibia from Ezh1^−/− mice 16.5 months after birth. Data are plotted as dots and the mean values are indicated as bars (WT, n = 5; Ezh1^−/−, n = 5). (D) Weights of the spleen and thymus from Ezh1^−/− mice 16.5 months after birth. Data are plotted as dots and the mean values are indicated as bars (WT, n = 5; Ezh1^−/−, n = 5). Statistical significance of difference was measured by unpaired 2-tailed Student t test. **P < .005.