Time course of anti-Xa and aPTT values (median, 95% confidence interval) comparing high-dose (100-U/kg bolus followed by continuous infusion) vs low-dose (50-U/kg bolus without continuous infusion) UFH dosing protocols. Yellow-shaded bars indicate therapeutic ranges. This figure has been adapted from Figure 1 in the article by Hanslik et al that begins on page 2091. Professional illustration by Patrick Lane, ScEYEnce Studios.