![The images referred to the same case at (A) disease onset, (B) first relapse, and (C) second relapse. The tumor consists of cells characterized by a clear rim of cytoplasm and TFH phenotype as defined by the expression of PD1, CXCL13, BCL6, CD10, and ICOS (not shown); in panel A, it has a “follicular” growth pattern (hematoxylin and eosin, ×20), and in panel B, it has the typical “angioimmunoblastic” appearance (please note the hyperplastic HEV and the inflammatory component [hematoxylin and eosin, ×400]). In panel C, the “angioimmunoblastic” characteristics are lost and neoplastic cells acquire at least in part a more blastic appearance (hematoxylin and eosin, ×400).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/126/15/10.1182_blood-2015-08-665075/4/1733f1.jpeg?Expires=1736059157&Signature=lc~BYcOSYkE9cS8IRqm9nwAjUk24IJsZL43O1i5gnlH~DOItneb6sqEW9kiFPFxX7rKxQH-R-MefZx29TNQ9MHkcEt9F0UBnOUG~aFa5m~65CNW4o09Kd9CPl~WsYMsSMt8hK~fqCnIHswKFBlKzyeW38yrOPyvr~2JirFda6uwYYEi5PX9pw1SpDAp8VCtepRN8c9nwLzNFs6o28WpvfR~U0GZz8lYudbJFXaHUt7NMtWXEBfZ-l4L9NOzUsbOWXcsPdx1~cdATS0CFXGEXjpn3y7dL9U8d8~wQMJBGucRKZZlMd3mwetIzAxTBgpPJmKmdsBgpupuhdFyRs8cWbw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The images referred to the same case at (A) disease onset, (B) first relapse, and (C) second relapse. The tumor consists of cells characterized by a clear rim of cytoplasm and TFH phenotype as defined by the expression of PD1, CXCL13, BCL6, CD10, and ICOS (not shown); in panel A, it has a “follicular” growth pattern (hematoxylin and eosin, ×20), and in panel B, it has the typical “angioimmunoblastic” appearance (please note the hyperplastic HEV and the inflammatory component [hematoxylin and eosin, ×400]). In panel C, the “angioimmunoblastic” characteristics are lost and neoplastic cells acquire at least in part a more blastic appearance (hematoxylin and eosin, ×400).
