Survival analysis of EMC92-ISS, FISH, and ISS. Kaplan-Meier plots and Cox regression model data are given. Kaplan-Meier plots are not stratified; Cox regression results are stratified (ie, corrected for differences in survival in different cohorts). (A) EMC92-ISS in the discovery set, (B) EMC92-ISS in the validation set, (C) EMC92-ISS in all data, (D) ISS in all data, (E) HR.FISH.A in all data, and (F) HR.FISH.B/ISS in all data. In order of increasing risk: low (blue); intermediate-low (purple); intermediate-high (orange); high (red). HR, high-risk; SR, standard-risk. Below the Kaplan-Meier curves, results of the stratified Cox model are found. Hazard, hazard ratio relative to the lowest risk group; P, P value relative to the lowest risk group; % positive, percentage of patients within the specified risk group. The bottom line shows the result of the likelihood ratio goodness-of-fit test.