Mutational profiles of IDH2, TET2, DNMT3A, and RHOA in patients with PTCLs. (A) Co-occurrence of IDH2^R172, TET2, DNMT3, and RHOA mutations in patients with AITL (n = 39), subgroups of PTCL-NOS (n = 41), and ALK(−) ALCL (n = 12). White color indicates wild-type cases. Gray color indicates cases with variant allele frequency (VAF) of ≥3% but <10%. Black color indicates cases with VAF of ≥10%. (B) Mutations occur in functional domains of the TET2 and DNMT3A proteins. Missense mutations, nonsense mutations, and insertion/deletions are indicated.