Genes with aberrant expression associated with aberrant methylation in AITL. RRBS methylation analysis (left) and gene expression analysis (right) are shown for 46 hypermethylated and 9 hypomethylated genes between 18 AITL and 7 normal samples. Gene selection criteria include promoters of the selected genes must be significantly hyper- or hypomethylated compared with normal tissue (3 tonsils and 4 CD4⁺ T-cell samples; P ≤ .05); selected genes must be normally expressed in primary CD4⁺ T cells; and there must be strong correlation between promoter methylation and gene expression among the samples (R < −0.4). Except for 1 case (indicated with *), all cases with RRBS data have corresponding gene expression data. Mutational statuses of IDH2^R172, TET2, and DNMT3A are listed at the top.