Poised genes tend to be downregulated and hypermethylated in IDH2^R172 mutant AITL. (A) GSEA analysis of genes differentially expressed between TET2-single mutant and IDH2/TET2-double mutant groups shows the enrichment of H3K27me3-associated genes. (B) Poised genes expressed in CD4⁺ T cells are downregulated in AITL with IDH2^R172 mutations. (C) Comparison of the DNA methylation patterns between poised genes and nonpoised genes in AITL, analyzing autosomal genes in the top half of mean gene expression in the 4 normal T-cell control samples. The poised genes are significantly more likely to be hypermethylated than nonpoised genes (P = 1.3 × 10⁻¹⁷, Fisher’s exact test).