The biological effect of MYC translocation in DLBCL may be modulated by additional parameters that include the IG or non-IG partner gene involved in the translocation, the association with an additional translocation of the BCL2 or BCL6 genes in the so-called DH, the tumor cell context in which the alteration occurs such DLBCL, GCB or ABC, BCLu, and other factors such as the MYC or BCL2 protein levels. Additional studies are needed to explore other aspects such as the influence of somatic mutations in the tumor. Professional illustration by Patrick Lane, ScEYEnce Studios.