Dexamethasone-induced apoptosis in T cells and its disruption by TALEN. (A) Pathway of steroid-induced apoptosis in T cells through the GR. —–, indirect effects. (B) Steroid resistance induced by electroporation of GR-Ex2–specific TALEN mRNA to block GR synthesis through disruption of the GR exon 2. F, Fokl nuclease domain for DNA cleavage; NHEJR, nonhomologous end-joining recombination.