American Society of Hematology

Figure 6

$Figure 6. NADPH oxidase deficiency did not result in intrinsic sensitivity to G-CSF. (A) Peripheral WBC and (B) ANC were determined 2 hours after IV injection with 5 μg of G-CSF or saline (n = 7). Data are presented as mean ± standard deviation. For panels A and B, P values were determined by analyzing the differences between control (Saline) and treated (G-CSF) experimental groups for each genotype by using the Student t test. *P < .05. (C) Cxcl2 expression was determined in total bone marrow 2 hours post-G-CSF injections. (D) Carrier females were injected with 5 μg of G-CSF and the relative fraction of oxidase-negative (DHR−) and oxidase-positive (DHR+) neutrophils determined by DHR assay. For panels C and D, data were analyzed using 1-way ANOVA with Tukey correction; ***P < .001 (C-D).$

NADPH oxidase deficiency did not result in intrinsic sensitivity to G-CSF. (A) Peripheral WBC and (B) ANC were determined 2 hours after IV injection with 5 μg of G-CSF or saline (n = 7). Data are presented as mean ± standard deviation. For panels A and B, P values were determined by analyzing the differences between control (Saline) and treated (G-CSF) experimental groups for each genotype by using the Student t test. *P < .05. (C) Cxcl2 expression was determined in total bone marrow 2 hours post-G-CSF injections. (D) Carrier females were injected with 5 μg of G-CSF and the relative fraction of oxidase-negative (DHR⁻) and oxidase-positive (DHR⁺) neutrophils determined by DHR assay. For panels C and D, data were analyzed using 1-way ANOVA with Tukey correction; ***P < .001 (C-D).

This Feature Is Available To Subscribers Only