Histology in LCDD. (A) Nodular glomerulosclerosis. High power view of a glomerulus exhibits mesangial expansion by periodic acid-Schiff–positive matrix that focally forms nodules with peripheral expansion producing lobules (periodic acid-Schiff stain, magnification ×400). (B) Granular electron dense deposits along the lamina rara interna of the glomerular basement membrane are seen on electron microscopy (magnification ×11 500). (C) Absence of specific mesangial staining with anti-λ antibodies, despite the presence of high background staining (magnification ×600).