Rate of change of GFR in relation to hematologic response. The scatter graph and plots below demonstrates the rate of change in GFR per year and the mean ± standard error of the mean for each dataset for patients with varying degrees of clonal response. GFR increased among those achieving either a hematologic CR or VGPR but declined among those who achieved only a PR or NR with chemotherapy (Mann-Whitney U test, P < .009).