Lymph node biopsy from a patient with EBV⁺ LBCL. The cells are pleomorphic including the presence of Hodgkin-like cells. Inset, the neoplastic B cells are positive for PAX5 (red nuclear stain) and strongly express PD-L1 (brown), which may inhibit the host antitumor response. Hematoxylin and eosin, original magnification ×250; inset, double immunostain for Pax5 (red) and PD-L1 (brown).