Targeting HGF/c-MET causes G2/M cell cycle arrest and DNA damage in KSHV⁺ PEL cells. (A) PEL cells were incubated with 0.4 µM PF-2341066 or vehicle control for 24 hours, then stained by PI and analyzed by flow cytometry. (B-D) The protein expression and DNA damage in BCBL-1 were measured by immunoblots and CometAssay, respectively. (E) The cellular expression of DNA damage markers phosphor-p53 and phosphor-H2A.X was detected by immunofluorescence, and the nuclear was shown by DAPI staining.