Cord blood T cells mediate enhanced antitumor effects compared with peripheral blood T cells. (A) Representative experiment illustrates slower tumor growth followed by rapid rejection of B-cell lymphoma in mice receiving allogeneic CB T cells compared with mice receiving allogeneic PB T cells and control mice. All images are shown on 1 scale (range, 1.00e8-1.00e9 photons/s/cm²/sr). Tumor size in control mice and those receiving PB T cells exceeded threshold of 10 mm, and hence these mice were euthanized. (B) Tumor bioluminescence (photons/s/cm²/sr) was measured using Xenogen-IVIS, and (C) tumor volume (mm³) was derived using caliper measurements. Cumulative rate of tumor growth (mean and standard error of mean) from 2 separate experiments are plotted. These plots show a significantly slower rate of tumor growth in the mice receiving CB T cells compared with the mice receiving PB T cells and the control group. (D) Regression of the tumor following infusion of CB T cells led to significantly improved survival in this group compared with the PB group (P < .0003).