CCR7 enriched CB CD8⁺ T cells have enhanced tumor-homing ability. (A) Normal donor CB CD8⁺ T cells have significantly higher expression of CCR7 compared with normal donor PB CD8⁺ T cells (expressed as mean and standard error of mean; n = 3 in each group; P < .005). (B) Offset histogram plot and (C) cumulative bar plot (mean and standard error of mean) showing fluorescence intensity of CD8⁺ T cells from normal donors and TILs and in circulation. This figure indicates that CCR7^highCD8⁺ T cells are primarily recruited to the tumor in both groups (P = not significant), and in the PB group, CCR7^lowCD8⁺ T cells remain in circulation (P < .01), indicating a role of CCR7-mediated chemotaxis in this tumor model.