Hematologic treatment reduces the onset of kidney deposits. (A) Therapeutic protocol applied to deplete B and plasma cells in CH1⁻ mice. (B) (Upper) Representative immunofluorescence on kidney sections of treated or nontreated CH1⁻ mice with an anti-human γHC-fluorescein isothiocyanate. Original magnification, ×400. (Lower) Comparison of deposit intensity in kidney sections of treated vs nontreated CH1⁻ mice. Each dot represents the score of fluorescence from an individual kidney. Means ± SEM are shown (n = 6-7 mice in 2 independent experiments; **P < .01).