Different amplification of early hematopoietic stem and progenitor cells in CALRdel52 and CALRins5 mice. (A) Evolution of the percentage of GFP⁺ cells in BM and spleen LSK and SLAM cell compartments (n = 3 to 5). (B) Frequency of BM and spleen LSK and SLAM cells of CALRwt, CALRdel52, or CALRins5 origin after 10 months transplantation (n = 5). Results are means ± SEM. Student t test: *P < .05, **P < .001, ***P < .0001.