Elevated plasma L5 levels in patients with ischemic stroke. (A) Representative results from FPLC with anion exchange columns showing the distribution of LDL subfractions in a patient with ischemic stroke and a normal control subject. The red circles indicate L5. The L5% is plotted for the control subjects and the ischemic stroke patients. (B) Agarose gel electrophoresis of plasma LDL from 3 normal control subjects (N1, N2, and N3) and from 3 patients with acute ischemic stroke (S1, S2, and S3). The arrow indicates the direction of electron flow. (C) Immunoprecipitation isolation and western blot analysis of Aβ secreted in the serum of control subjects or patients with ischemic stroke (n = 8). (D) Western blot analysis of LOX-1 expression on the platelets of control subjects or patients with ischemic stroke (n = 8). Quantified results are expressed as the mean ± SD; P values were determined by using the Wilcoxon signed-rank test. **P < .01; ***P < .001 vs the control group. HC, heavy chain of IgG antibody; mAU, milliabsorbance units.