Effect of L5 and Aβ on tail-bleeding time in C57BL/6 mice. Tail-bleeding times were determined after treatment with vehicle (injection of 40 μL of saline with the administration of 3% Tween 80 [5 mL/kg] via oral gavage), L5 injection (5 mg/kg), Aβ injection (1 mg/kg), or L5+Aβ injection with or without the administration of BMS-345541 (10 mg/kg in 3% Tween 80) via oral gavage (2 hours before the tail-bleeding time experiment³⁸ ) into adult male C57BL/6 mice. Data represent the time of tail amputation to the time of blood flow cessation for >10 seconds. Bar graphs show compiled data (n = 12). *P < .05, **P < .01 vs vehicle-treated control mice; #P < .05 vs L5+Aβ-treated mice.