Figure 4
Figure 4. Impaired B-cell development in Wip1KO mice is exacerbated by aging and serial transplantation. The number of total B cells in the bone marrow of WT and Wip1KO mice at a young (2 months, A) and old (20-24 months, B) age is summarized. The number of the developing B cells, including pre-pro–B, pro-B, pre-B, immature B, and mature B cells in the bone marrow of WT and Wip1KO mice at a young (C) and old (D) age is shown. Data are expressed as means ± SD (n ≥ 12). (E-H) The bar graphs show the number of B, pre-pro–B, pro-B, pre-B, immature B, and mature B cells in donor-derived BMCs 20 weeks after the first transplantation (E-F) and after the third transplantation (G-H). Data are expressed as means ± SD (n = 8). *P < .05, **P < .01, and ***P < .001 compared with WT mice or between the indicated groups. BM, bone marrow.

Impaired B-cell development in Wip1KO mice is exacerbated by aging and serial transplantation. The number of total B cells in the bone marrow of WT and Wip1KO mice at a young (2 months, A) and old (20-24 months, B) age is summarized. The number of the developing B cells, including pre-pro–B, pro-B, pre-B, immature B, and mature B cells in the bone marrow of WT and Wip1KO mice at a young (C) and old (D) age is shown. Data are expressed as means ± SD (n ≥ 12). (E-H) The bar graphs show the number of B, pre-pro–B, pro-B, pre-B, immature B, and mature B cells in donor-derived BMCs 20 weeks after the first transplantation (E-F) and after the third transplantation (G-H). Data are expressed as means ± SD (n = 8). *P < .05, **P < .01, and ***P < .001 compared with WT mice or between the indicated groups. BM, bone marrow.

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