Increased erythropoiesis in Gpx4^Δ mice depends on vitamin E. (A) Schematic overview of treatment: bone marrow from Gpx4^F/F or Mx1-Cre/Gpx4^F/F mice was transplanted (BMT) into wild-type recipients; mice were kept on a vitamin E–depleted diet (VitE^Δ) after the recovery; and deletion was induced by poly(I:C). Red blood cell counts (B), hemoglobin levels (C), hematocrit (D), and reticulocyte counts (E). Data are mean ± SE; n ≥ 4. Enlarged spleens (F) and elevated serum EPO levels (G) in transplanted mice. Data are mean ± SE; n ≥ 6. ***P < .001, **P < .01, *P < .05 by Student t test.