Genetic deletion of Rip3 normalizes red cell parameters and rescues anemia. Normalization of red blood cell counts (A), hemoglobin levels (B), and hematocrit (C), and reduction of reticulocyte numbers (D). Enlarged spleens (E) and elevated serum EPO levels (F) in Gpx4^Δ mice are normalized upon deletion of Rip3. Data are mean ± SE; n ≥ 9. (G) Quantification of TUNEL⁺ cells in spleen sections. (H) Flow cytometry analysis of AnnexinV⁻PI⁺ erythroid progenitor cells in the spleen. Data are mean ± SE; n ≥ 4. *P < .05, **P < .01, ***P < .001 by ANOVA/Bonferroni.