Regulation of neutrophil infiltration, degranulation, and oxidative stress by platelets during the peritoneal rpA reaction. (A) Comparison of neutrophil content in peritoneal lavage fluids from control wild-type, thrombocytopenic, and GPVI^−/− mice that were subjected or not to the rpA reaction in the peritoneal cavity. (B-D) Quantification and comparison of MMP-9 (B) and MPO (C) protein levels and of oxidative stress (D) in peritoneal lavage fluids from control wild-type, thrombocytopenic, and GPVI^−/− mice subjected to the peritoneal rpA reaction. Each dot corresponds to a mouse. (E-G) MMP-9 (E) and MPO (F) degranulation indexes and oxidative index (G) of mice subjected to the peritoneal rpA reaction Degranulation and oxidative indexes were calculated by dividing levels of MMP-9, MPO, and oxidative activity measured in lavage fluids by the number of infiltrating neutrophils. Each dot represents 1 mouse. NS, not significant.