Absence of leukemia abrogates CAR-induced GVHD. (A) Survival curves (top) and percent weight change (bottom) of leukemia-bearing B6 mice (gray), C3h.sw mice (red), and nonleukemic C3h.sw mice (cyan) receiving an allogeneic TCD BMT followed by CAR on day 2. Survival graphs indicate pooled data from 2 replicate experiments. (B) Splenocytes of C3h.sw leukemic mice (red), C3h.sw nonleukemic mice (cyan), and B6 leukemic mice (white) recipients of B6 TCD-BMT and CAR T cells were harvested on day 7 and enumerated. *P < .05; **P < .01.