Platelets from Pf4-Lox^tg/tg mice have enhanced aggregation to monomeric collagen. (A) Platelet aggregation in response to monomeric collagen in WT (n = 8) and Pf4-Lox^tg/tg platelets (n = 6). *P < .01, **P < .001. (B) Representative aggregation trace at 5 μg/mL of monomeric collagen. (C-F) Platelet aggregation in response to fibrillar collagen in WT and Pf4-Lox^tg/tg platelets (n = 3 per genotype) (C), to thrombin in WT (n = 7) and Pf4-Lox^tg/tg platelets (n = 6) (D), to adenosine 5′-diphosphate (ADP) in WT (n = 7) and Pf4-Lox^tg/tg platelets (n = 6) (E), and to U46619 in WT and Pf4-Lox^tg/tg platelets (n = 5 per genotype) (F). Data represented as average ± SD.