Inhibition of αIIbβ3 integrin reduces platelet accumulation and vessel sealing. (A) Representative images of thrombi formed in the presence of either vehicle (left) or eptifibatide (right) (20 mg/kg), showing both platelets (blue) and fibrin (red) 3 minutes postinjury. (B) Average platelet area and (C) fibrin area for both the vehicle-treated (black) and eptifibatide-treated (white) thrombi (± SEM). (D) Representative images of cAlb extravasation (green) at both 30 and 180 seconds postinjury for vehicle (top) and eptifibatide treated (bottom) thrombi (platelets are denoted in blue). (E) Time course and (F) dot plot of relative cAlb extravasation for vehicle (black) and eptifibatide (white) treated thrombi (vehicle n = 12, eptifibatide n = 11; ± SEM).
