Pten loss in CD45-expressing cells leads to development of T-ALL. (A) Complete blood cells counts showing total number of leukocytes, lymphocytes, and myeloid cells in CD45:Cre^−/−Pten^f/f and CD45:Cre^+/−Pten^f/f mice. (B-D) Quantification of flow cytometry analysis of blood (B), spleen (C), and bone marrow (D) from CD45:Cre^−/−Pten^f/f and CD45:Cre^+/−Pten^f/f mice. (E-G) Representative images of CD3, CD4, and CD8 immunhistochemistry in blood (E), spleen (F), and bone marrow (G) from CD45:Cre^−/−Pten^f/f and CD45:Cre^+/−Pten^f/f mice. Data are means ± standard deviation; *P ≤ .05; ***P ≤ .0001.