Disturbed shaping of the repertoire in memory B-cell compartment. Heat map representing the frequency of V-D gene combinations in naïve and switched memory B cell of (A) healthy donors (HDs) and (B) P1 and (C) P2. For P2, memory B cells have been divided by Fas-deficient (FAS^{c.3G>T/c.3G>T}) and Fas-competent (FAS^wt/c.3G>T). Numbers below the map indicate the total number of productive sequences represented. Color scale indicates the relative frequency of each combination. Data obtained by deep sequencing of immunoglobulin variable region genes.