American Society of Hematology

Figure 4

$Figure 4. Comparison of mutant allele fraction between primary tumor and associated PDX model. We plotted the mutant allele fraction (frequency of a mutation at a particular locus) in the primary tumors (x-axis) and the associated PDX models (y-axis). SNVs in genes reported to be mutated in at least 1 of 4 DLBCL sequencing series are represented in gray, and SNVs in genes reported to be mutated in at least 2 of 4 DLBCL sequencing series are labeled in red (supplemental Table 2A19-22). Multiple SNVs in the same gene are noted (PIM1 in LTL-005, KMT2D in LTL-025, and POU2F2 in LTL-034). Mutant allele fractions along the diagonal (x = y, identical mutant allele fractions, dotted line) indicate similar clonal frequencies in the primary tumor and associated PDX model. Mutant alleles that are more abundant in the PDX model than in the primary tumors are above the diagonal. Allele fractions ±0.2 from the identical mutant allele fractions are visualized in gray.$

Comparison of mutant allele fraction between primary tumor and associated PDX model. We plotted the mutant allele fraction (frequency of a mutation at a particular locus) in the primary tumors (x-axis) and the associated PDX models (y-axis). SNVs in genes reported to be mutated in at least 1 of 4 DLBCL sequencing series are represented in gray, and SNVs in genes reported to be mutated in at least 2 of 4 DLBCL sequencing series are labeled in red (supplemental Table 2A^19-22). Multiple SNVs in the same gene are noted (PIM1 in LTL-005, KMT2D in LTL-025, and POU2F2 in LTL-034). Mutant allele fractions along the diagonal (x = y, identical mutant allele fractions, dotted line) indicate similar clonal frequencies in the primary tumor and associated PDX model. Mutant alleles that are more abundant in the PDX model than in the primary tumors are above the diagonal. Allele fractions ±0.2 from the identical mutant allele fractions are visualized in gray.

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